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Synthesis and antimicrobial activity of 6-aryl-3,4-dimethyl-N-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides |
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| Authors: | T. M. Zamaraeva T. F. Odegova A. Yu. Fedotov M. V. Tomilov V. L. Gein P. A. Slepukhin |
| Affiliation: | 1. Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation, ul. Polevaya 2, Perm, 614990, Russia 2. Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, Yekaterinburg, Russia 3. B.N. Yeltsin Ural Federal University, Yekaterinburg, Russia |
| Abstract: | Three-component reaction of acetoacetanilide, aromatic aldehydes, and N-methylurea afforded 6-aryl-3,4-dimethyl-N-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides. IR, 1H NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis data confirmed the structure of the compounds obtained. Antimicrobial activity of these compounds was investigated. |
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