| Synthesis and Characterization of PEG-scuteilarin Conjugates, a Potential PEG Ester Prodrug for the Oral Delivery of Scutellarin |
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| 作者姓名： | Qing Song ZHOU Xue Hua JIANG Jia Rui YU Ke Jia LI |
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| 作者单位： | West China School of Pharmacy, Sichuan University, Chengdu 610041 |
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| 基金项目： | Acknowledgments This work was supported by the National Natural Science Foundation of China （No. 30070935; 30271614） |
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| 摘 要： | Highly water soluble esters of scutellarin with variable molecular weight polyethylene glycol （PEG） were prepared via PEGylation. The physicochemical properties and the stabilities under different conditions were investigated. By PEG modification, the greatly increased water solubility and desirable partition coefficient of scuteUarin were obtained, and the results showed that these conjugates were potential prodrugs for the oral delivery of scuteUarin.
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| 关 键 词： | 合成 表征 聚乙二醇 黄芩素 药物前体 物理化学性质 稳定性 中药 |
| 收稿时间： | 2005-01-27 |
| 修稿时间： | 2005-10-19 |
Synthesis and Characterization of PEG-scuteilarin Conjugates, a Potential PEG Ester Prodrug for the Oral Delivery of Scutellarin |
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| Qing Song ZHOU Xue Hua JIANG Jia Rui YU Ke Jia LI.Synthesis and Characterization of PEG-scuteilarin Conjugates, a Potential PEG Ester Prodrug for the Oral Delivery of Scutellarin[J].Chinese Chemical Letters,2006,17(1):85-88. |
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| Authors: | Qing;Song;ZHOU;Xue;Hua;JIANG;Jia;Rui;YU;Ke;Jia;LI |
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| Abstract: | |
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| Keywords: | Scutellarin PEGylation prodrug physicochcmical properties stability |
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