| 组合表面活性剂-盐-水双水相体系萃取水杨酸和洛美沙星 |
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| 引用本文： | 李蕾,薛珺,练萍,刘芳华,温相斌.组合表面活性剂-盐-水双水相体系萃取水杨酸和洛美沙星[J].分析化学,2004,32(1):96-98. |
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| 作者姓名： | 李蕾 薛珺 练萍 刘芳华 温相斌 |
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| 作者单位： | 赣南师范学院化学与生命科学系,赣州,341000;赣南师范学院化学与生命科学系,赣州,341000;赣南师范学院化学与生命科学系,赣州,341000;赣南师范学院化学与生命科学系,赣州,341000;赣南师范学院化学与生命科学系,赣州,341000 |
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| 基金项目： | 江西省自然科学基金 (No .0 3 2 0 0 2 1)，江西省教育厅科技发展基金 (No .2 0 0 112 3 0 )资助课题 |
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| 摘 要： | 通过实验选择聚乙二醇(PEG1500)与聚乙烯吡咯烷酮(PVP30000)组合表面活性剂(NH4)2SO4-H2O形成双水相体系及其成相条件。研究水杨酸(APC)和洛美沙星(LFXC)氢键型药物在该双水相体系中的分配行为。结果表明：该体系对APC和LFXC的萃取率分别为102％和69．0％。通过药物在该体系中的紫外吸收光谱及分子荧光光谱的变化，验证其萃取药物的机理。
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| 关 键 词： | 双水相体系 组合表面活性剂 萃取 水杨酸 洛美沙星 |
Hydroxybenzoic Acid and Lomefloxacin Extraction in the Agueous Two-Phase System Based on Combination Surfactants-Salt-Water |
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| Li Lei ,Xue Jun,Lian Ping,Liu Fanghua,Wen Xiangbin.Hydroxybenzoic Acid and Lomefloxacin Extraction in the Agueous Two-Phase System Based on Combination Surfactants-Salt-Water[J].Chinese Journal of Analytical Chemistry,2004,32(1):96-98. |
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| Authors: | Li Lei Xue Jun Lian Ping Liu Fanghua Wen Xiangbin |
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| Institution: | Li Lei *,Xue Jun,Lian Ping,Liu Fanghua,Wen Xiangbin |
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| Abstract: | The phase separation conditions for aqueons two-phase system based on polyethylene glycol(PEG)1500-polyvinyl pyrrolidone(PVP)30,000-Salt-H 2O were examined. The extraction behaviours of two hydrogen bonding drugs hydroxybenzoic acid (APC) and lomefloxacin (LFXC) were carried out in this system. The experimental results showed that the extraction efficiency of APC was 102%, while that of LFXC was 69.0%. Through the comparison of different conditions and research on the ultraviolet and fluorescence spectra of drugs, the extraction mechanism of drugs was deduced. |
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| Keywords: | Aqueous two-phase system combination surfactants extraction hydroxybenzoic acid lomefloxacin |
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