| 4, 5-二氮芴-9-酮Cu(II)、Co(II)多核配合物的合成，晶体结构及DNA结合作用初探 |
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| 引用本文： | 张荣兰a,赵建社a,席小莉b,杨频b,史启祯 a. 4, 5-二氮芴-9-酮Cu(II)、Co(II)多核配合物的合成，晶体结构及DNA结合作用初探[J]. 中国化学, 2008, 26(7): 1225-1232. DOI: 10.1002/cjoc.200890223 |
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| 作者姓名： | 张荣兰a 赵建社a 席小莉b 杨频b 史启祯 a |
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| 作者单位： | a陕西物理无机化学重点实验室，西北大学化学系，陕西·西安 710069，中国 ;b化学生物学与分子工程教育部重点实验室，山西大学分子科学研究所，山西·太原 030006，中国 ; |
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| 摘 要： | 合成了两个4, 5-二氮芴-9-酮Cu(II)、Co(II)的多核配合物[Cu2(CH3COO)4(H2O) 2]·2dafo 1 和 [(μ2-O)2-Co3(dafo)6] (ClO3)2·H2O 2 (dafo=4,5-diazafluoren-9-one) 并且对它们进行了元素分析，红外以及紫外光谱的表征，同时测定了配合物的晶体结构。用紫外光谱，发射光谱和循环伏安三种方法初步研究了配合物1和2与DNA的结合作用，结果表明，配合物1和2与DNA的结合为以插入作用为主 。
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| 关 键 词： | 合成 多核配合物 晶体结构 DNA结合作用 |
| 收稿时间： | 2007-11-05 |
| 修稿时间： | 2008-01-07 |
Characterization,Crystal Structure and Initial DNA Binding Mechanism Research of Multi‐nuclear Homometallic Complexes of 4,5‐Diazafluoren‐9‐one with Copper(II) and Cobalt(II) |
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| Rong‐Lan ZHANG,Jian‐She ZHAO,Xiao‐Li XI,Pin YANG,Qi‐Zhen SHI. Characterization,Crystal Structure and Initial DNA Binding Mechanism Research of Multi‐nuclear Homometallic Complexes of 4,5‐Diazafluoren‐9‐one with Copper(II) and Cobalt(II)[J]. Chinese Journal of Chemistry, 2008, 26(7): 1225-1232. DOI: 10.1002/cjoc.200890223 |
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| Authors: | Rong‐Lan ZHANG Jian‐She ZHAO Xiao‐Li XI Pin YANG Qi‐Zhen SHI |
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| Affiliation: | 1. Shaanxi Key Laboratory of Physico‐inorganic Chemistry, Department of Chemistry, Northwest University,Xi'an, Shaanxi 710069, China;2. Fax: 0086‐29‐88303798;3. Chemical Biology and Molecular Engineering Laboratory of Education Ministry, Institute of Molecular Science, Shanxi University, Taiyuan, Shanxi 030006, China |
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| Abstract: | Two new multi‐nuclear homometallic complexes, [Cu2(OAc)4(H2O)2]·2dafo ( 1 ) and [(µ2‐O)2‐Co3(dafo)6]‐(ClO3)2·H2O ( 2 ) (dafo=4,5‐diazafluoren‐9‐one), were synthesized. The two complexes have been fully characterized by elemental analysis, IR, absorption spectra, emission spectra, and single‐crystal X‐ray diffraction analysis. The initial DNA binding mechanisms of the two complexes have been investigated by absorption spectra, emission spectra and cyclic voltammograms. Both complexes show similar perturbations on addition of calf thymus DNA in the UV region, their luminescence intensities in aqueous buffer are all enhanced in the presence of increasing amounts of DNA, and their electrochemical behavior is both completely different in the absence and presence of DNA. The results of the three methods indicate that the spectral characters and the electrochemical behavior of the two complexes are very similar to those of the known metallointercalators. So it can be concluded that the action mode of the two complexes with DNA is mainly intercalative. |
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| Keywords: | synthesis multi‐nuclear homometallic complex crystal structure DNA binding interaction |
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