Evaluation of homology modeling of the severe acute respiratory syndrome (SARS) coronavirus main protease for structure based drug design |
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| Authors: | Takeda-Shitaka Mayuko Nojima Hiroyuki Takaya Daisuke Kanou Kazuhiko Iwadate Mitsuo Umeyama Hideaki |
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| Institution: | School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan. shitakam@pharm.kitasato-u.ac.jp |
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| Abstract: | To accelerate the development of drugs against severe acute respiratory syndrome (SARS), we constructed a homology model of the SARS coronavirus main protease using our modeling software, FAMS Ligand&Complex, and released it before the X-ray structure was solved. The X-ray structure showed our model as accurately predicted and useful for structure based drug design. |
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