Preparation of Pseudo-Arsonolipids: Dl-2,3-Diacyloxybutane-1,4-Bis(Arsonic Acids) |
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Authors: | Panayiotis V Ioannou |
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Institution: | Department of Chemistry , University of Patras , GR 26500 , Patras , Greece |
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Abstract: | Abstract The title pseudo-arsonolipid with palmitoyl side chain has been prepared in ~70% yield from its parent DL-2,3-dihydroxybutane-1,4-bis(arsonic acid) after reduction of the As(V) to As(III) by thiophenol, acylation with palmitoyl chloride in the presence of pyridine and catalytic amounts of 4-(dimethylamino)pyridine, and reoxidation of As(III) to As(V) by hydrogen peroxide. In CDCl3/CD3OD esterification of the –AsO3H2 groups was detected by 1H NMR. |
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Keywords: | Pseudo-arsonolipids 2 3-dihydroxybutane-1 4-bis(arsonic acids) DL-2 3-diacyloxybutane-1 4-bis(arsonic acids) acylation |
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