The Reaction of N-Isocyaniminotriphenylphosphorane With Biacetyl in the Presence of (E)-Cinnamic Acids: Synthesis of Fully Substituted 1,3,4-Oxadiazole Derivatives via Intramolecular AZA-Wittig Reactions of in Situ Generated Iminophosphoranes |
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| Authors: | Ali Ramazani Behnaz Abdian Fatemeh Zeinali Nasrabadi Morteza Rouhani |
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| Affiliation: | 1. Department of Chemistry , University of Zanjan , Zanjan , Iran;2. Young Researchers Club, Zanjan Branch , Islamic Azad University , Zanjan , Iran |
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| Abstract: | Abstract Reaction of N-isocyaniminotriphenylphosphorane with biacetyl in the presence of (E)-cinnamic acids proceeds smoothly at room temperature and under neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives in high yields. The reaction proceeds smoothly and straightforward under mild conditions and no side reactions are observed. |
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| Keywords: | N-isocyaniminotriphenylphosphorane biacetyl (E)-cinnamic acid 1,3,4-oxadiazole aza-Wittig reaction |
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