Investigation on the Acylation of Heterocyclic Alcoholate Anions with O,O-Dialkyl Phosphorochloridothioate in Water Solvent |
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| Authors: | Xin Ge Chao Qian Xinzhi Chen |
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| Affiliation: | Key Laboratory of Biomass Chemical Engineering of Ministry of Education , Zhejiang University , Hangzhou , China |
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| Abstract: | Abstract The acylation of some heterocyclic alcoholate anions with O,O-dialkyl phosphorochloridothioate has been investigated. Higher yields and fewer byproducts were achieved in water at 50 °C by employing an effective phase-transfer catalyst (PTC) (benzyl triethylammonium chloride [BTEAC]), acylation catalyst (AC) (4-dimethylaminopyridine), and surfactant (sodium dodecyl sulfate), under weakly basic (pH 9.5～10) conditions. This reaction can also be applied to synthesize other insecticides with excellent yields. |
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| Keywords: | Acylation heterocyclic alcoholate anion O,O-dialkyl phosphorochloridothioate |
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