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Stereoselective Synthesis of Trisubstituted Olefins |
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| Authors: | Scott E Denmark Jack S Amburgey |
| Institution: | 1. Department of Chemistry , University of Illinois at Urbana-Champaign , Urbana, Illinois, 61801, USA;2. Department of Chemistry , University of Illinois at Urbana-Champaign , Urbana, Illinois, 61801, USA;3. Procter &4. Gamble Pharmaceuticals, Miami Valley Laboratories , P. O. Box 538707, Cincinnati, Ohio, 45253, USA |
| Abstract: | Abstract A new method for the highly stereoselective synthesis of trisubstituted olefins is. presented. The method involves the stereoselective construction of various β-hydroxy phosphonamidates followed by their thermolysis to provide trisubstituted olefins in extremely high geometrical purity (>99/1). |
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