Highly chemoselective and efficient Strecker reaction of aldehydes with TMSCN catalyzed by MgI2 etherate under solvent-free conditions |
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Authors: | Huijun Liu Kailun He Jing Zhou |
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Institution: | College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, P. R. China |
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Abstract: | AbstractStrecker reaction of various substituted aromatic aldehydes, heteroaromatic aldehydes, aliphatic aldehydes and α,β-unsaturated aldehydes with trimethylsilyl cyanide (TMSCN) was realized in the presence of 5?mol % of MgI2 etherate in a mild, efficient and highly chemoselective manner under solvent-free conditions. |
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Keywords: | Aldehyde trimethylsilyl cyanide Strecker reaction MgI2 etherate |
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