Highly chemoselective and efficient Strecker reaction of aldehydes with TMSCN catalyzed by MgI2 etherate under solvent-free conditions |
| |
| Authors: | Huijun Liu Kailun He Jing Zhou |
| |
| Institution: | College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, P. R. China |
| |
| Abstract: | AbstractStrecker reaction of various substituted aromatic aldehydes, heteroaromatic aldehydes, aliphatic aldehydes and α,β-unsaturated aldehydes with trimethylsilyl cyanide (TMSCN) was realized in the presence of 5?mol % of MgI2 etherate in a mild, efficient and highly chemoselective manner under solvent-free conditions. |
| |
| Keywords: | Aldehyde trimethylsilyl cyanide Strecker reaction MgI2 etherate |
|
|
