Regioselective Synthesis of 3-Benzylthiazolo[3,2-a]pyrimidones and 3-Benzyl-thiazolo[3,2-c]pyrimidones Through Palladium-Catalyzed Heteroannulation of Acetylenic Compounds |
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| Authors: | Majid M. Heravi Ali Kivanloo Mohammad Rahimizadeh Mehdi Bakavoli Mitra Ghassemzadeh Bernhard Neumüller |
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| Affiliation: | 1. Ferdowsi University of Mashhad, Iran and Azzahra University, Vanak , Tehran, Iran;2. Ferdowsi University of Mashhad , Iran;3. Chemistry and Chemical Engineering, Research Center of Iran , Tehran, Iran;4. Fachbereich Chemie der Philipps-Universit?t , Marburg, Germany |
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| Abstract: | Abstract The reaction of 2-(prop-2-ynylsulfanyl)pyrimidone 1 with various iodobenzenes in the presence of a palladium catalyst leads to regioselective cyclization to 3-benzylthiazolo [3,2-a] pyrimidones 3. The reaction of 4-(prop-2-ynylsulfanyl) pyrimidone 5 with various iodobenzenes in the same condition give the corresponding 3-benzylthiazolo[3,2-c]pyrimidones 6. |
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| Keywords: | Keywords Acetylenic compounds palladium-catalyzed heteroannulation regioselective cyclization thiazolopyrimidines |
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