Tungstophosphoric Acid Supported on Zirconia: A Recyclable Catalyst for the Green Synthesis on Quinoxaline Derivatives under Solvent-Free Conditions |
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Authors: | Alexis A Sosa Toa S Rivera Mirta N Blanco Luis R Pizzio Gustavo P Romanelli |
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Institution: | Centro de Investigación y Desarrollo en Ciencias Aplicadas “Dr. Jorge J.J. Ronco” (CINDECA), Departamento de Química, Facultad de Ciencias Exactas, UNLP-CCT La Plata CONICET , 1900 , La Plata , Argentina |
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Abstract: | Abstract A green, simple, and fast procedure has been developed for the preparation of quinoxaline derivatives by a condensation of 1,2-diamines with 1,2-dicarbonyl compounds in the presence of zirconium oxide modified with tungstophosphoric acid (H3PW12O40) as a heterogeneous catalyst, in a solvent-free medium using conventional heating. Quinoxaline derivatives were formed in short-time periods and excellent yields (65–100%). The reaction work-up is very simple and the catalyst can be easily separated from the reaction mixture and reused several times in subsequent reactions without appreciable loss of the catalytic activity. Supplementary materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfer, and Silicon and the Related Elements for the following free supplemental files: Additional text. |
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Keywords: | Quinoxalines tungstophosphoric acid mesoporous zirconia ecofriendly process solvent-free condition |
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