An Efficient and Convenient Protocol for the Synthesis of Thiazolidin-4-Ones |
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Authors: | S Ebrahimi A Mobinikhaldei H Eibagi |
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Institution: | 1. Department of Chemistry, Malayer Branch , Islamic Azad University , Malayer, Iran;2. Department of Chemistry , Arak University , Arak, Iran |
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Abstract: | Abstract Without a catalyst and under solvent-free conditions, 2,3-disubstituted-1,3-thiazolidin-4-one 5a–j derivatives were synthesized efficiently via the three-component reaction of aryl hydrazide, aromatic aldehyde, and mercaptoacetic acid. All the newly synthesized compounds were confirmed by IR, 1H NMR, and 13C NMR spectroscopy and elemental analysis. GRAPHICAL ABSTRACT ![id=](/na101/home/literatum/publisher/tandf/journals/content/gpss20/2011/gpss20.v186.i12/10426507.2011.608099/production/images/medium/gpss_a_608099_o_uf0001.gif) |
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Keywords: | Thiazolidin-4-one multicomponent isonicotinohydrazide nicotinohydrazide mercaptoacetic acid |
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