An Efficient and Convenient Protocol for the Synthesis of Thiazolidin-4-Ones |
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| Authors: | S Ebrahimi A Mobinikhaldei H Eibagi |
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| Institution: | 1. Department of Chemistry, Malayer Branch , Islamic Azad University , Malayer, Iran;2. Department of Chemistry , Arak University , Arak, Iran |
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| Abstract: | Abstract Without a catalyst and under solvent-free conditions, 2,3-disubstituted-1,3-thiazolidin-4-one 5a–j derivatives were synthesized efficiently via the three-component reaction of aryl hydrazide, aromatic aldehyde, and mercaptoacetic acid. All the newly synthesized compounds were confirmed by IR, 1H NMR, and 13C NMR spectroscopy and elemental analysis. GRAPHICAL ABSTRACT  |
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| Keywords: | Thiazolidin-4-one multicomponent isonicotinohydrazide nicotinohydrazide mercaptoacetic acid |
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