QSAR in Reactions of Organophosphorus Inhibitors with Acetylcholinesterase |
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| Authors: | Aavo Aaviksaar |
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| Institution: | Laboratory of Bioorganic Chemistry , Institute of Chemical Physics and Biophysics of the Estonian Academy of Sciences , Tallinn , 200026, P.O. Box, 670 , USSR |
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| Abstract: | Abstract Structure-activity relationships in inhibition of acetylcholinesterase by organophosphorus compounds (YO)(Z)P(O)SX have been analyzed using the equation log ki = C + ρσ + ?π with Taft σ* for substituent elehtronegativity and Hansch Π for hydrophobicity. The obtained relationships have been used for optimizing the structures of organophosphorus inhibitors for their maximum anticholinesterase activity. |
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| Keywords: | 1 2 4-Oxadiazole-5(4H)-thione Copper-catalysed rearrangement 1 2 4-thiadiazole-5(4H)- ones |
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