The Design and Synthesis of Bone-Active Phosphinic Acid Analogues: 1. The Pyridylaminomethane Phosphonoalkylphosphinates |
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| Authors: | Frank H. Ebetino Laura A. Jamieson |
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| Affiliation: | Product Development , Nonvich Eaton Pharmaceuticals, Inc. A Procter and Gamble Company , P.O. Box 191, Nonvich , N.Y. , 13815 |
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| Abstract: | Abstract The bisphosphonic acids and their salts, the bisphosphonates, have been the subject of study by a number of research groups for their marked ability to modulate bone metabolism. From a recent study of phosphinic acid isosteres, we have designed a novel related class of bone active agents, the pyridylaminomethane phosphonoaikylphosphinates I. |
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| Keywords: | Key words: Germylated phosphonates and thiophosphonates germylated heterocycles germanone germanethione |
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