31P NMR Determination of the Urinary Excretion of the Antitumor Drug Cyclophosphamide in Humans |
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| Authors: | Claire Joqueviel Robert Martino Veronique Gilard Myriam Malet-martino Ulf Niemeyer |
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| Affiliation: | 1. IMRCP Laboratory , Université Paul Sabatier , 118, route de Narbonne, 31062 , Toulouse , France;2. ASTA Medica AG , Frankfurt am Main , Germany |
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| Abstract: | Abstract 31P NMR was used to analyze urine from 4 patients treated with cyclophosphamide (CP) over 2 days. CP and most of its phosphorated metabolites (carboxyCP (CXCP), dechloroethylCP (DCCP), alcoCP, ketoCP and phosphoramide mustard (PM)) were assayed. Several other signals (10- 15) corresponding to unknown compounds were observed. Seven new compounds were identified: all were hydrolysis products of CP or its metabolites CXCP, DCCP and PM as reported below. |
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