Synthesis and Biological Activities of Novel 1,4-Bridged Bis-1,2,4-Triazoles,Bis-1,3,4-Thiadiazoles and Bis-1,3,4-Oxadiazoles |
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| Authors: | R. M. Shaker A. F. Mahmoud F. F. Abdel-Latif |
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| Affiliation: | Chemistry Department, Faculty of Science , El-Minia University , El-Minia, A. R.Egypt |
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| Abstract: | Abstract The terephthalic acid hydrazide(1) reacted with phenyl/benzyl isothiocyanate2a,bto yield the corresponding bis-thiosemicarbazides4a,b,viaacid hydrolysis of the intermediate 3whereas cyclization of4gave the bis-1,2,4-triazoles 5,6and bis-1,3,4-thiadiazoles7,8. Similarly, compound 1reacted with phenyl isocyanate9to give the bis-semicarbazide10, which was cyclized to the bis-oxadiazole 11and/or bis-1,2,4-triazole12in POClti3and NaOH respectively. |
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| Keywords: | bis-1,3,4-oxadiazoles bis-1,3,4-thiadiazoles bis-thiosemicarbazides terephthalic acid hydrazide |
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