Symmetrical and Unsymmetrical Bishophonate Esters Chemistry: Synthesis,Selective Hydrolysis,Isomerization |
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Authors: | Driss El Manouni Marc Lecouvey Gerard Leger Mohammed Karim Yves Leroux |
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Institution: | Laboratoire de chimie structurale biomoléculaire (URA 1430 - CNRS) , 74, rue Marcel Cachin, 93017 , BOBIGNY , FRANCE |
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Abstract: | Abstract Over thc past few years, bisphosphonatcs have bcen receiving increased auention as a new class of pharmacologically active compound. As a continuation of our research program (1,2,3) in connection with the synthesis of bisphosphonate esw I. we present here some results about thc synthesis of symmetrical and unsymmcuical bisphosphonate esms. These compounds were selectively hydrolizcd to give the following mono, di, d and tcua acids II. |
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