Fluorinated 1-Methylaminoalkylphosphonates. Interaction with Ammonia and Methylamine

Previously we reported that fluorinated aminophosphonates 1a react with NH₃ to form heterocyclic salts 2 1,2]. As was found, 2 eliminate NH₃ under heating to give neutral 1,4,2-diazaphospholines 3. The reverse reaction of 3 with NH₃, any amines, and alkalis led to the same aniones 2. Salts 2 and diazaphospholines 3 are hydrolyzing by moisture of ammonia or solvents into betaines 4.