A Novel Synthesis of 2-Alkylthiobenzothiazoles and 2-Alkylthiobenzoxazoles |
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| Authors: | Yanfei Yu Zhengning Li Lan Jiang |
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| Affiliation: | 1. College of Environmental and Chemical Engineering , Dalian University , Dalian , China;2. College of Environmental and Chemical Engineering , Dalian University , Dalian , China;3. Liaoning Key Laboratory of Bioorganic Chemistry , Dalian University , Dalian , China |
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| Abstract: | Abstract 3H-Benzothiazole-2-thione and 3H-benzoxazole-2-thione were selectively S-alkylated by use of O-alkylisoureas as the alkylating reagents. The reactions could be performed under mild reaction conditions in short reaction times, and high yields were obtained using O-primary-alkylisoureas, whereas low yields were obtained with sec- and tert-alkylisoureas. |
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| Keywords: | Synthesis 2-alkylthiobenzothiazole 2-alkylthiobenzoxazole O-alkylisourea alkylation |
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