NaHSO4.H2O Catalyzed Multicomponent Synthesis of 1-(Benzothiazolylamino) Methyl-2-Naphthols Under Solvent-Free Conditions |
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Authors: | Asghar Hosseinian Hamid Reza Shaterian |
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Affiliation: | Department of Chemistry, Faculty of Sciences , University of Sistan and Baluchestan , Zahedan , Iran |
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Abstract: | A one-pot, efficient three-component condensation of aldehydes, 2-naphthol, and 2-aminobenzothiazole in the presence of sodium hydrogen sulfate as an effective catalyst for the synthesis of 1-(benzothiazolylamino)methyl-2-naphthol derivatives under thermal and solvent-free conditions is described. These products involve two biologically active parts, Betti's base and benzothiazole. The present methodology offers several advantages, such as good yields, short reaction times, and easy work-up. |
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Keywords: | 1-(Benzothiazolylamino)methyl-2-naphthols benzothiazole Betti's base multicomponent reaction |
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