New Directions in the Development of Water-Soluble Phosphines and Transition Metal Compounds |
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| Authors: | Kattesh V Katti V Sreenivasa Reddy Prahlad R Singh Douglas E Beming Charles J Smith Wynn A Volkert |
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| Institution: | Center for Radiological Research and MU Research Reactor University of Missouri , Columbia, Missouri, 65203, USA |
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| Abstract: | Abstract The water-soluble bisphosphines, 1,2-bis(bis(hydroxymethyl)phosphino)benzene (“HMPB”) (1) and 1,2-bis(bis(hydroxymethyl)phosphino)ethane (“HMPE”) (2) were synthesized in near quantitative yields by the catalytic hydroformylation of H2PC6H4PH2 and H2PCH2CH2PH2 in the presence of formaldehyde in aqueous media.1.2 The reactions of these chelating bisphosphines 1 and 2 with Pt(COD)Cl2 and Pd(PhCN)2Cl2 produced water-soluble Pt(II) and Pd(II) complexes M(HOH2C)2PC6H4P(CH2OH)2]2Cl2 (M = Pt, 3; Pd, 4) and M(HOH2C)2PCH2CH2P(CH2OH)2]2Cl2 (M = Pt, 5; Pd, 6) respectively. The reactions of 1 and 2 with Re(O2)I(Ph3)2 and Re(O)2(NHC5H5)4]Cl to produce new water-soluble Re(V) complexes are also described. All the new compounds were characterized by 1H and 31P NMR spectroscopy. X-ray structures of representative Pd(II) and Re(V) complexes as shown below confirmed the chemical constitution of this new generation of water-soluble metal complexes. |
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