SYNTHESIS AND ANTICANCER SCREENING OF DIASTEREOISOMERIC 4,5-DIPHENYL- AND 3-METHYL-4,5-DIPHENYLCYCLOPHOSPHAMIDES |
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| Authors: | Milena Ivanova Maria Lyapova Zlatina Astardjieva Jordan Stoychkov |
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| Institution: | 1. Institute of Organic Chemistry with Center of Phytochemistry, Bulgarian Academy of Sciences , 1040, Sofia, Bulgaria;2. Department of Experimental Cancer Therapy , Medical Academy , 1156, Sofia |
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| Abstract: | Abstract The four possible diastereoisomers of 4,5-diphenylcyclophosphamides (2–5) and their N-methyl analogues (6–9) have been synthesized via condensation of aminopropanols 10 and 11 (threo- and erythro) with bis-(2-chloroethyl)-phosphoramidic dichloride 12. Anticancer screening tests against L 1210 lymphoid leukaemia in mice did not show any therapeutic activity. |
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| Keywords: | Diastereoisomeric 4 5-diphenylcyclophosphamides anticancer screening |
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