Synthesis,characterization and evaluation of novel benzothiazole clubbed chromene derivatives for their anti-inflammatory potential |
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Authors: | Divyani Gandhi Dinesh Kr Agarwal Priyanka Kalal Amit Bhargava Dinesh Jangid |
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Institution: | 1. Department of Chemistry, Mohanlal Sukhadia University, Udaipur, India;2. Department of Pharmacy, Bhupal Noble University, Udaipur, India;3. Department of Chemistry, University of Rajasthan, Jaipur, India |
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Abstract: | AbstractA series of chromene derivatives (5a–f) were prepared by multistep synthesis process using 2-3-phenyl prop-2-ene nitrile] 1,3-benzothiazole and dimedone using piperidine as catalyst in ethanol. The reaction was found to proceed via Knoevenagel condensation of aldehydes with benzothiazole, followed by the elimination to afford the 2-(benzod]thiazol-2-yl)-3-(aryl)acrylonitrile, which then undergoes Michael addition with 5,5-dimethyl-1,3-cyclohexanedione, followed by intramolecular O-cyclization to give the products. The structures of all novel constructed derivatives were corroborated by elemental analysis and spectral data (FT-IR, 1H-NMR, 13C-NMR and Mass). Subsequently, the compounds were tested for their in-vivo anti-inflammatory activity. This study revealed that these synthesized derivatives tend to have significantly anti inflammatory activity and shall prove as structural templates in the design and development of new anti inflammatory drugs. |
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Keywords: | 2-Aminobenzenethiol chromene carrageenan-induced paw edema anti inflammatory |
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