A Green and Efficient Approach for the Synthesis of 3-Chalcogen Benzo[b]Furans via I2-Mediated Cascade Annulation Reaction of 2-Alkynylanisoles at Room Temperature in Water期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

A Green and Efficient Approach for the Synthesis of 3-Chalcogen Benzo[b]Furans via I2-Mediated Cascade Annulation Reaction of 2-Alkynylanisoles at Room Temperature in Water

Authors:	Jiang-Sheng Han Yin-Lin Shao Xiao-Hong Zhang Ping Zhong

Affiliation:	1. College of Chemical and Materials Engineering, Wenzhou University , Wenzhou , China;2. College of Chemical and Materials Engineering, Wenzhou University , Wenzhou , China;3. Oujiang College, Wenzhou University , Wenzhou , China

Abstract:	Abstract An efficient and green aqueous protocol to access 3-chalcogen benzo[b]furan derivatives has been developed. The reaction can proceed via I₂-mediated intramolecular annulation reaction of 2-alkynylanisoles with diaryl disulfides (diselenides) in water or under solvent-free conditions at room temperature. With the participation of I₂, a variety of 3-chalcogen benzo[b]furan derivatives were obtained in good to excellent yields. This reaction was considered to work via an iodocyclization cascade mechanism and the intermediate 3-iodo-2-phenylbenzofuran was detected by GC-MS.

Keywords:	3-chalcogen benzo[b]furans I₂-mediated intramolecular annulation