Investigation on the One-Step Preparation of 2-Substituted Benzo[B]Thiophenes |
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| Authors: | Qian Zhao Chao Qian Xin-Zhi Chen |
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| Institution: | Department of Chemical and Biological Engineering, Key Laboratory of Biomass Chemical Engineering of Ministry of Education , Zhejiang University , Hangzhou , China |
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| Abstract: | Abstract A convenient and efficient synthesis of 2-substituted benzob]thiophenes is described. This one-step reaction of alkylthiobenzaldehyde and activated electrophiles proceeded smoothly in toluene at 120 °C with magnesium oxide as a catalyst. The target 2-substituted benzob]thiophenes are obtained in moderate yields and the side reaction is inhibited via azeotropic distillation. According to the experiments, a plausible mechanism is presented. |
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| Keywords: | 2-Substituted benzo[b]thiophenes aldol condensation mechanism |
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