Facile Construction of Medium-Sized Carbocycles,Total Synthesis of (±)-Parvifoline |
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| Authors: | Erich L Grimm Sylvain Levac Michel L Coutu |
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| Institution: | Merck Frosst Centre for Therapeutic Research , P.O. Box 1005 Pointe Claire-Dorval, Quebec, H9R 4P8, Canada |
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| Abstract: | Abstract A new synthetic approach to medium-sized rings has been accomplished via intramolecular cyclization of a sulfone-stabilized carbanion. This strategy was applied to the total synthesis of (±)-parvifoline. |
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| Keywords: | hydroxyaryl phosphine ligand heterocycle phosphen aroxydiphosphine |
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