N-Isocyaniminotriphenylphosphorane (Ph3PNNC) as an Efficient Reagent for the Synthesis of Fully Substituted 1,3,4-Oxadiazoles from 3-Phenyl-2-Propynoic Acid,Secondary Amines and Aromatic Bis-Aldehydes |
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| Authors: | Hamideh Ahankar Ali Ramazani Yavar Ahmadi Issa Amini |
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| Affiliation: | 1. Department of Chemistry, Abhar Branch , Islamic Azad University , Abhar , Iran;2. Department of Chemistry, Zanjan Branch , Islamic Azad University , Zanjan , Iran;3. Department of Chemistry , University of Zanjan , Zanjan , Iran;4. Department of Chemistry , Payame Noor University , Tehran , Iran |
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| Abstract: | Abstract Reactions of N-isocyaniminotriphenylphosphorane (Ph3PNNC) with aromatic bis-aldehydes (isophthalaldehyde and terphthalaldehyde) in the presence of 3-phenyl-2-propynoic acid and secondary amines proceed smoothly at room temperature and in neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives in high yields. The reaction proceeds smoothly and cleanly under mild conditions and no side reactions were observed. |
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| Keywords: | N-isocyaniminotriphenylphosphorane bis-aldehydes 3-phenyl-2-propynoic acid secondary amines 1,3,4-oxadiazole |
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