Thia- and Sulfonyl-Calix[4]Arene Methylphosphonous Acids: Synthesis,Structure, and Amino Acids Binding |
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| Authors: | S. G. Kharchenko A. B. Drapailo O. I. Kalchenko G. D. Yampolska S. V. Shishkina O. V. Shishkin |
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| Affiliation: | 1. Institute of Organic Chemistry, National Academy of Sciences of Ukraine , Kyiv , Ukraine;2. Institute for Single Crystals, National Academy of Sciences of Ukraine , Kharkiv , Ukraine |
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| Abstract: | Abstract Thia- and sulfonyl-calix[4]arene methylphosphonous acids have been synthesized by hydrolysis of corresponding alkyl esters. Host-Guest complexation of the thiacalix[4]arene tetrakis-methylphosphonous acid with a series of 12 amino acids has been investigated by HPLC and molecular modeling methods. Stability constants of the complexes are within 530—10,140 M?1 in water contained solution. |
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| Keywords: | Thiacalixarenes phosphonous acids amino acids supramolecular complexes HPLC molecular modeling |
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