Synthesis and Antimicrobial Activities of Some 1-[(N,N-Disubstitutedthiocarbamoylthio)acetyl]-3,5-diaryl-2-pyrazolines |
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| Authors: | Gülhan Turan-Zitouni Ahmet Özdemir Zafer Asim Kaplancikli Pierre Chevallet Yagmur Tunali |
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| Institution: | 1. Department of Pharmaceutical Chemistry , Anadolu University, Faculty of Pharmacy , Eski?ehir, Turkey;2. Department of Pharmaceutical Chemistry , Montpellier University, LAAP , Montpellier, France;3. Department of Microbiology , Anadolu University, Faculty of Pharmacy , Eski?ehir, Turkey |
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| Abstract: | The increasing clinical importance of drug-resistant fungal and bacterial pathogens has lent additional urgency to microbiological research and new antimicrobial compound development. For this purpose, new pyrazoline derivatives were synthesized and evaluated for antimicrobial activity. Some 1-(N, N-disubstitutedthiocarbamoylthio)acetyl]-3,5-diaryl-2-pyrazolines derivatives were synthesized by reacting 1-(chloroacetyl)-3,5-diaryl-2-pyrazolines with appropriate potassium salts of secondary amine dithiocarbamic acids. The chemical structures of the compounds were elucidated by IR, 1 H-NMR, and FAB+-MS spectral data. Their antimicrobial activities against Staphylococcus aureus (B-767), Escherichia coli (B-3704), Pseudomonas aeruginosa (ATCC 27853), Proteus vulgaris (NRLL B-123), and Candida albicans (NRRL-27077) were investigated. The results showed that some of the compounds have notable activity against S. aureus and C. albicans. |
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| Keywords: | Antimicrobial activity dithiocarbamic acid pyrazoline |
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