The Interaction of Thioethynyl Esters of Thiophosphoric Acids with Cytochrom P 450 |
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| Authors: | N N Godovikov L A Vikhreva T A Pudova M I Kabachnik |
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| Institution: | A.N. Nesmeyanov Institute of Organoelement Compounds RAS , Moscow, Russia |
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| Abstract: | Abstract We have shown that thioesters of phosphoric acids of general formula (RO)2P(X)Ctbnd]CR1, were X=O or S, containing an acetylenic bond in α-position of the S-ester group has unugually high destructive effect on some isoforms of cytochrome P 450 of arthropods and mammals. These isoforms probably, participate in the process of inactivation of the acetylenic thioesters. We assume that this process may be thought as being a rupture of rhe P-S bond, which leads to the formation of killer particles - alkylthioketenes. |
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