Remarkably Fast and Mild Solvent-Free Conversion of Epoxides into Thiocyanohydrins Using Mukaiyama Reagent |
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| Authors: | Roya Azadi Babak Mokhtari Hanifeh Oghabi |
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| Institution: | Department of Chemistry, College of Science , Shahid Chamran University , Ahvaz , 61357-43337 , Iran |
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| Abstract: | Abstract A mild and operationally simple method for the synthesis of thiocyanohydrins is described. Mukaiyama reagent is used as an effective reagent for the solvent-free conversion of epoxides into their corresponding thiocyanohydrins. The reactions were completed in <5 min to give thiocyanohydrins with perfect regioselectivity and isolated yields. |
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| Keywords: | Mukaiyama reagent 2-chloro-1-methylpyridinium iodide ring opening epoxide thiocyanohydrin solvent-free |
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