N-Isocyaniminotriphenylphosphorane as an Efficient Reagent for the Synthesis of Disubstituted 1,3,4-Oxadiazoles Via In-Situ Generation of Sterically Congested Iminophosphorane Derivatives |
| |
| Authors: | Ali Ramazani Mona Ashtari Ali Souldozi Yavar Ahmadi |
| |
| Affiliation: | 1. Department of Chemistry , Zanjan University , Zanjan , Iran;2. Department of Chemistry , Payame Noor University , Tehran , Iran;3. Department of Chemistry, Urmia Branch , Islamic Azad University , Urmia , Iran;4. Young Researchers Club, Zanjan Branch , Islamic Azad University , Zanjan , Iran |
| |
| Abstract: | Abstract Reaction of N-isocyaniminotriphenylphosphorane with benzaldehyde derivatives in the presence of 3-phenyl-2-propynoic acid and secondary amines proceeds smoothly at room temperature and under neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives in high yields. The reaction proceeds smoothly and cleanly under mild conditions and no side reactions are observed. |
| |
| Keywords: | aza-Wittig iminophosphorane 1,3,4-oxadiazole 3-phenyl-2-propynoic acid, secondary amine |
|
|
