One-Pot Three-Component Synthesis of 3-Methyl-4-Arylmethylene- Isoxazol-5(4H)- Ones Catalyzed by Sodium Sulfide |
| |
| Authors: | Qing Liu Xianming Hou |
| |
| Institution: | Department of Chemistry and Environmental Science , Taishan University , Tai’an , China |
| |
| Abstract: | Abstract 3-Methyl-4-arylmethylene-isoxazol-5(4H)-ones were synthesized by the convenient three-component reaction of ethyl acetoacetate, hydroxylamine hydrochloride, and aromatic aldehydes catalyzed by sodium sulfide in the presence of ethanol at room temperature. The advantages of this procedure were mild reaction conditions, high yields, short reaction time, and operational simplicity. |
| |
| Keywords: | Sodium sulfide 3-methyl-4-arylmethylene-isoxazol-5(4H)-ones one-pot synthesis |
|
|
