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Isolation and Characterisation of All Four Diastereomeric Intermediates from a Horner-Wittig Reaction |
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| Authors: | Laura J Parry Victoria Vinader Ian J Scowen Vipul K Patel Kamyar Afarinkia |
| Institution: | 1. Institute of Cancer Therapeutics, University of Bradford , Bradford , United Kingdom;2. Analytical Center, University of Bradford , Bradford , United Kingdom;3. Medicines Research Center, GlaxoSmithKline , Stevenage , United Kingdom |
| Abstract: | Abstract The Horner-Wittig reaction between diphenyl(2-phenylpropyl)phosphine oxide and 1-naphtaldehyde affords an equal mixture of the cis and trans isomers even though the formation of the initial adduct is selective. |
| Keywords: | Horner-Wittig alkene mechanism |