Synthesis of Some Pyrazolo[3, 4]pyrimidine Derivatives for Biological Evaluation |
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Authors: | A H Shamroukh A E Rashad H H Sayed |
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Institution: | Photochemistry Department , National Research Centre, Dokki , Cairo, Egypt |
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Abstract: | Abstract A novel β -enaminonitrile of 1-(6-p-tolyl-pyridazin-3-yl)-pyrazole derivative 2 was formed using (6-p-tolyl-pyridazin-3-yl)-hydrazine ( 1 ) and 2-ethoxymethylenemalononitrile. The β-enaminonitrile derivative 2 was in turn used as a precursor for the preparation of pyrazoles ( 4 , 6 ), pyrazolo3, 4-d]-pyrimidines ( 3 , 7–12 ) and pyrazolo4, 3-e]1,2,4]triazolo4,3-c]pyrimidine ( 13 ). Also, N- and S-acyclic nucleosides 14 and 15 were prepared. Some of the prepared products showed potent antimicrobial activity. |
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Keywords: | β-enaminonitrile acyclic nucleosides pyrazole pyrazolo[3 4-d]pyrimidine pyrazolo-[4 3-e]-[1 2 4]triazolo[4 3-c] pyrimidine |
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