Synthesis and Tuberculostatic Activity of 1,3-Thiazacycloalkyl[3,2-b]-1,2,4-triazoles |
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Authors: | Barbara Milczarska Henryk Foks Urszula Dobrzycka Zofia Zwolska Ewa Augustynowicz-Kopeć |
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Institution: | 1. Department of Organic Chemistry , Medical University of Gdańsk , Poland;2. Department of Microbiology , Institute of Tuberculosis and Pulmonary Diseases , Warsaw, Poland |
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Abstract: | The 4-hydroxyalkyl-1,2,4-triazole-3-thiones cyclization allowed us to work out the effective method of 1,3-thiazacycloalkyl3,2-b]-1,2,4-triazoles synthesis. Some of the compounds that were obtained were tested for their tuberculostatic activity. |
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Keywords: | 1 3-Thiazacycloalkyl[3 2-b]-1 2 4-triazoles 4-hydroxyalkyl-1 2 4-triazole-3- thiones methyl 2-acylodithiocarbazates tuberculostatic |
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