Microwave-Assisted Direct Synthesis of 4H-1,2,4-Benzothiadiazine 1,1-Dioxide Derivatives |
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| Authors: | Jelem Restrepo José Salazar Simón E López |
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| Institution: | Laboratory of Heterocycles and Medicinal Chemistry, Department of Chemistry , Universidad Simón Bolívar , Apartado, 89000, Venezuela |
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| Abstract: | Abstract We describe a rapid and convenient methodology for the preparation of diverse 3-aryl and 3-trifluoromethyl 4H-1,2,4-benzothiadiazine-1,1-dioxides in a one-pot microwave-promoted reaction between 2-aminobenzenesulfonamides and benzaldehydes, trifluoroacetic acid or benzoic acids. GRAPHICAL ABSTRACT  |
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| Keywords: | 1 2 4-Benzothiadiazines sodium hydrogen sulfite microwave irradiation 2-aminobenzenesulfonamides trifluoroacetic acid benzoic acids |
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