A Study on the Phosphorylation of Indole,Imidazole, Carbazole,and Phenothiazine Derivatives |
| |
| Authors: | Mátyás Milen Péter Ábrányi-Balogh György Balogh László Drahos György Keglevich |
| |
| Affiliation: | 1. Department of Organic Chemistry and Technology , Budapest University of Technology and Economics , Budapest , Hungary;2. EGIS Pharmaceuticals Plc. , Division for Chemical Research , Budapest , Hungary;3. Department of Organic Chemistry and Technology , Budapest University of Technology and Economics , Budapest , Hungary;4. Gedeon Richter Plc. , Budapest , Hungary;5. Hungarian Academy of Sciences , Chemical Research Center , Budapest , Hungary |
| |
| Abstract: | Abstract N-Heterocycles including indolecarbaldehyde, substituted benzimidazoles, and methylimidazole could be efficiently phosphorylated by diethyl chlorophosphate at room temperature in different solvents using alkali carbonate or triethylamine as the base. However, the phosphorylation of N-heterocycles with a lower reactivity at the NH function, such as carbazole and phenothiazine, could not be conducted to complete conversion under the conditions applied. |
| |
| Keywords: | N-heterocycles phosphorylation indoles imidazoles carbazole phenothiazine |
|
|
