New synthesis of estradiol from androsta-1,4-diene-3,17-dione |
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| Authors: | L L Vasiljeva P M Demin D M Kochev M A Lapitskaya K K Pivnitsky |
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| Institution: | (1) N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 117913 Moscow, Russian Federation;(2) “Pentcroft Pharma” Company, Post box 544, 119021 Moscow, Russian Federation |
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| Abstract: | A new method for the aromatization of ring A in androsta-1,4-diene-3,17-dione, available from sterols by means of the microbiological
degradation of the side chain, was developed. The method consists of the reduction of androsta-1,4-diene-3,17-dione to the
corresponding dienediol followed by double C,O-deprotonation of ring A, accompanied by expulsion of the 19-methyl group and
formation of estradiol in a high yield.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 599–601, March, 1999. |
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| Keywords: | androsta-1 4-diene-3 17-dione aromatization angular demethylation estradiol partial synthesis |
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