| 5,7-二甲基-1,2,4-三唑并[1,5-a]嘧啶-2-甲酰腙类化合物的合成与生物活性 |
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| 引用本文： | 龙德清,汪焱钢,李德江,王锋尖. 5,7-二甲基-1,2,4-三唑并[1,5-a]嘧啶-2-甲酰腙类化合物的合成与生物活性[J]. 有机化学, 2005, 25(11): 1498-1502 |
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| 作者姓名： | 龙德清 汪焱钢 李德江 王锋尖 |
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| 作者单位： | 1. 郧阳师范高等专科学校化学系,丹江口,442700
2. 华中师范大学化学学院,武汉,430079 |
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| 摘 要： | 以5-氨基-1H-1,2,4-三唑-3-羧酸为起始原料, 设计合成了13个新型的5,7-二甲基-1,2,4-三唑并[1,5-a]嘧啶-2-甲酰腙类化合物, 通过1H NMR, MS和元素分析对所合成的化合物进行了结构表征. 初步的生物活性测试结果表明, 所合成的化合物均表现出不同程度的除草及杀菌活性, 其中化合物4b, 4h和5m的活性较好, 在50 mg/L浓度下对水稻纹枯病菌的抑制率达90 %以上.
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| 关 键 词： | 1,2,4-三唑并[1,5-a]嘧啶 甲酰腙 合成 生物活性 |
| 收稿时间： | 2005-04-28 |
| 修稿时间： | 2005-09-14 |
Synthesis and Biological Activity of 2-Benzylidenehydrazinocar-bonyl-5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine |
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| LONG,De-Qing,WANG,Yan-Gang,LI,De-Jiang,WANG,Feng-Jian. Synthesis and Biological Activity of 2-Benzylidenehydrazinocar-bonyl-5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine[J]. Chinese Journal of Organic Chemistry, 2005, 25(11): 1498-1502 |
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| Authors: | LONG De-Qing WANG Yan-Gang LI De-Jiang WANG Feng-Jian |
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| Affiliation: | a.Department of Chemistry, Yunyang Teachers College, Danjiangkou 442700;b.College of Chemistry, Central China Normal University, Wuhan 430079 |
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| Abstract: | Thirteen novel 2-benzylidenehydrazinocarbonyl-5,7-dimethyl-1,2,4-triazolo[5,1-a]pyrimidine derivatives were designed and synthesized by using 5-amino-1,2,4-triazole-3-carboxylic acid as a starting material. All compounds synthesized were confirmed by 1H NMR, MS spectra and elemental analyses. Pre- liminary bioassay indicates that some compounds display herbicidal activity and excellent fungicidal activity to some extent, among them the compounds 5b, 5h and 5m exhibited higher than 90% inhibition effect against Rhizoctonia solani in dosage of 50 mg/L. |
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| Keywords: | 1 2 4-triazolo[1 5-a]pyrimidine carbonylhydrazone synthesis biological activity |
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