具有聚集诱导发光性质的近红外荧光染料

聚集诱导发光(AIE)现象的发现为解决传统有机荧光分子在高浓度和聚集形态下存在的荧光猝灭问题提供了最佳方案,并实现了在光电器件、化学传感、生物成像和靶向治疗等众多领域的广泛应用.随着对AIE 发光机理研究的不断深入,AIE 分子体系得到了极大的扩展.其中,一类具有给体-受体结构的AIE分子能够显著降低分子能隙,使发光分...

Near Infrared Fluorescent Dyes with Aggregation-Induced Emission

The discovery of the aggregation-induced emission(AIE)phenomenon provides the best solution to solve the problem of fluorescence quenching of traditional organic fluorescent molecules at high concentrations and aggregation state.AIE molecules are widely used in many fields such as photoelectric devices,chemical sensing,biological imaging and targeting therapy.With the deepening of the research on the emissive mechanism of AIE,the AIE molecular system has been greatly expanded.Among them,a class of AIE molecules with donor-acceptor structures can significantly reduce the molecular energy gap and extend the emission wavelengths of molecules from the visible light region(400~700 nm)to the near infrared(NIR)region(700~1700 nm).Due to the unique advantages of NIR fluorescent molecules in the field of biomedicine,they have become the hot topic of AIE research.With the continuous exploration of the design and application of NIR molecules,AIE molecules with different functions and longer emission wavelengths have also been developed,and realized the application of NIR fluorescence imaging,photoacoustic imaging,photodynamic therapy and photothermal therapy to specific tissues of organisms.This article summarizes the structure of NIR fluorescent molecules with AIE performance in recent years and their related applications in the field of biomedicine.