| 2-(取代苯氨基)苯并咪唑合成方法的改进 |
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| 引用本文： | 徐云根,罗穗,华维一.2-(取代苯氨基)苯并咪唑合成方法的改进[J].化学通报,2004,67(11):862-864. |
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| 作者姓名： | 徐云根 罗穗 华维一 |
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| 作者单位： | 中国药科大学新药研究中心,南京,210009;中国药科大学新药研究中心,南京,210009;中国药科大学新药研究中心,南京,210009 |
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| 摘 要： | 在酸催化下，邻苯二胺和取代苯基异硫氰酸酯在HgO或HgCl2存在下，经缩合—脱硫环合得2—(取代苯氨基)苯并咪唑。该方法具有条件温和、反应迅速、收率高等特点。利用波谱分析和元素分析对新化合物5a进行了结构表征。
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| 关 键 词： | 苯并咪唑 苯基异硫氰酸酯 氧化汞 氯化汞 |
Improved Synthesis of 2-[(4-Acetamido)phenylamino] benzimidazole |
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| Xu Yungen,Luo Sui,Hua Weiyi.Improved Synthesis of 2-[(4-Acetamido)phenylamino] benzimidazole[J].Chemistry,2004,67(11):862-864. |
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| Authors: | Xu Yungen Luo Sui Hua Weiyi |
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| Abstract: | Arylaminobenzimidazole was conveniently synthesized from o-phenylenediamine by condensation-cyclodesulphurization with arylisothiocyanate in the presence of mercuric oxide(or mercuric chloride) and conc hydrochloric acid. The reaction was readily performed with good yields under mild conditions. The new compound 5a was characterized by +1H NMR, MS, IR and elemental analysis. |
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| Keywords: | Benzimidazole derivatives Phenylisothiocyanate Mercuric oxide Mercuric chloride |
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