4-Oxo-3,4-dihydroquinazolinyl- and Benzimidazolylacetonitriles in Annelation Reactions of a Haloquinoline Ring |
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| Authors: | O. V. Khilya T. A. Volovnenko A. V. Turov Yu. M. Volovenko |
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| Affiliation: | (1) Kiev Taras Shevchenko National University, Kiev, 01033, Ukraine |
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| Abstract: | The interaction of 4-oxo-3,4-dihydroquinazolinyl- and benzimidazolylacetonitriles with 2,6-dihalobenzaldehydes leads to 3-(2,6-dihalophenyl)-2-(4-oxo-3,4-dihydro-2-quinazolinyl)acrylonitriles and 2-(1H-benzo[d]imidazol-2-yl)-3-(2,6-dihalophenyl)acrylonitriles respectively. As a result of intramolecular cyclization of these nitriles 4-halo-12-oxo-12H-quino[2,1-b]quinazoline-6-carbonitriles and 4-halobenzo[4,5]imidazo[1,2-a]quinoline-6-carbonitriles respectively are formed. |
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| Keywords: | benzimidazolylacetonitrile 2-(1H-benzo[d]imidazol-2-yl)-3-(2,6-dihalophenyl)acrylonitriles 4-halobenzo[4,5]imidazo[1,2-a]quinoline-6-carbonitriles 4-halo-12-oxo-12H-quino[2,1-b]-quinazoline-6-carbonitriles 3-(2,6-dihalophenyl)-2-(4-oxo-3,4-dihydro-2-quinazolinyl)acrylonitriles 4-oxo-3,4-dihydroquinazolinylacetonitrile |
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