A novel oxidative decarboxylation—synthesis of 2-amino-1,2-dihydroisoquinoline-3(4H)-one and its amide derivatives from tetrahydroisoquinoline-3-carboxylic acid |
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| Authors: | B Gopalan Mani UmamaheswariPS Mohan Sridharan Rajagopal |
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| Institution: | a Department of Medicinal Chemistry, Orchid Research Laboratories Limited, R&D Centre, Plot #476/14, Old Mahabalipuram Road, Sozhanganallur, Chennai 600 119, India
b Department of Chemistry, Bharathiar University, Coimbatore, India |
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| Abstract: | A convenient method of synthesizing 2-amino-1,2-dihydroisoquinoline-3(4H)-one and its amide derivatives (4 or 5) is described through sydnone intermediate (3) derived from TIC (1) (tetrahydroisoquinoline-3-carboxylic acid) under acidic conditions in good yield. |
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