Exceptionally high in vitro antitumor activity of substituted triphenyltin benzoates including salicylates against a human mammary tumor,MCF-7, and a colon carcinoma,WiDr

Nine new substituted triphenyltin benzoates of the type Ar₃Sn? OOC? C₆H₂XYZ [X = Y = H, Z = 2-OCH₃ and 4-F; X = H, Y = 3-F, Z = 5-F; X = H, Y = 2-OH, Z = 5-Cl, 5-NH₂, 5-OCH₃ and 5-SO₃H; X = 2-OH, Y = 3-CH(CH₃)₂ and Z = 5-CH(CH₃)₂] were prepared and possess considerable in vitro antitumor activity against two human tumor cell lines (MCF-7, a mammary tumor, and WiDr, a colon carcinoma) comparable with that of mitomycin C.