Facile synthesis of a library of lyme disease glycolipid antigens |
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| Authors: | Jean-d'Amour K Twibanire Raha Parvizi Omran T Bruce Grindley |
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| Affiliation: | Department of Chemistry, Dalhousie University , 6274 Coburg Road, P.O. Box 15000, Halifax, NS, Canada B3H 4R2. |
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| Abstract: | A library of one of the two Lyme disease antigens, BbGL1, has been synthesized in four steps from d-galactose using BF(3)-promoted glycosylation of the peracetate to introduce the cholesteryl β-glycoside and TBTU-promoted esterification to add a range of fatty acids regioselectively at O-6 of d-galactose in good yield. |
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