Synthesis of water-soluble, multiple functionalizable dendrons for the conversion of large dendrimers or other molecular objects into potential drug carriers |
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Authors: | Müller Stephan Schlüter A Dieter |
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Institution: | Institut für Chemie/Organische Chemie, Freie Universit?t Berlin, Takustrasse 3, 14195 Berlin, Germany. |
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Abstract: | The synthesis of dendrons and dendrimers which carry OEG chains and bidentate ligands and/or fluorescence tags is described. The orthogonally protected functional groups of the dendrons allow modification of the substitution pattern and attachment to larger entities. Both dendrons and dendrimers are highly water-soluble. The dendrons should have considerable potential to convert, for example, commercially available, high-generation dendrimers into water-soluble, versatile support materials for antitumor therapy. |
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Keywords: | dendrimers drug delivery macromolecules |
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