Dynamic coating of a capillary with room-temperature ionic liquids for the separation of amino acids and acid drugs by capillary electrophoresis |
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| Authors: | T -F Jiang Y -H Wang Z -H Lv |
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| Institution: | (1) Key Laboratory of Marine Drugs (Ocean University of China), Ministry of Education, China;(2) Key Laboratory of Marine, Drugs of Shangdong Province, China;(3) Marine Drug and Food Institute, Ocean University of China Quingdao, 266003, China |
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| Abstract: | A room-temperature ionic liquid (IL), 1-ethyl-3-methyl-imidazolium tetrafluoroborate (1E-3MI-TFB), used for the coating of
a silica capillary enables one to reduce or invert the electroosmotic flow (EOF) in capillary zone electrophoresis. Excellent
separations of amino acids and ary lalkanoic acids were obtained. Such separations could not be obtained in a naked capillary
in the presence of the cationic surfactants cetyltrimethylammonium bromide (CTAB) or polycationic polymer hexadimethrine bromide
(HDB). The results indicate that 1E-3MI-TFB not only modulates the EOF but also acts as a discriminator. Further experiments
indicate that the interaction between hydrogen at C-2 carbon of IL and acid drugs plays an important role in the separation.
The text was submitted by the authors in English. |
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