An ion conductor that recognizes osmotically-stressed phospholipid bilayers |
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| Authors: | Bandyopadhyay Prasun Bandyopadhyay Punam Regen Steven L |
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| Affiliation: | Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania 18015, USA. |
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| Abstract: | A synthetic ion conductor (1), derived from cholic acid and spermine, has been found capable of recognizing osmotic stress in liposomes made from 1,2-dipalmitoleoyl-sn-glycero-3-phosphocholine [(C16:1)PC]. Thus, when large unilamellar vesicles of (C16:1)PC are placed under hypotonic conditions, the Na+/Li+ transport activity of 1 increases by as much as 1 order of magnitude, relative to isotonic conditions |
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